{"id":9151,"date":"2022-04-28T17:39:52","date_gmt":"2022-04-28T12:09:52","guid":{"rendered":"https:\/\/polscienceweb.com\/?post_type=portfolio&#038;p=9151"},"modified":"2022-04-28T17:40:12","modified_gmt":"2022-04-28T12:10:12","slug":"new-self-amplifying-covid-19-mrna-vaccine-shows-promising-results","status":"publish","type":"portfolio","link":"https:\/\/polscienceweb.com\/index.php\/portfolio\/new-self-amplifying-covid-19-mrna-vaccine-shows-promising-results\/","title":{"rendered":"New self-amplifying COVID-19 mRNA vaccine shows promising results"},"content":{"rendered":"\n<h4 class=\"has-text-align-center wp-block-heading\">Data so far promises a new, lower-dose vaccine that is easier to distribute and cheaper<\/h4>\n\n\n<div class=\"has-text-align-center wp-block-post-date\"><time datetime=\"2022-04-28T17:39:52+05:30\">28th April 2022<\/time><\/div>\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<details class=\"wp-block-verse\" style=\"font-size: 18.5px; text-align: justify;\">\n<summary class=\"wo-block-verse\" style=\"font-size: 18.5px; text-align: center;\">Read more<br><br><\/summary>\n\n\n\n<p class=\"wp-block-verse\" style=\"font-size: 18px; text-align: justify;\">A <strong>self-amplifying mRNA vaccine<\/strong> &#8211; one in which the delivered RNA multiplies inside the body &#8211; has shown promising results against Covid-19 in ongoing phase 1\/2\/3 trials, according to a study published in <a href=\"https:\/\/www.science.org\/content\/article\/mrna-vaccine-twist-it-copies-itself-protects-against-covid-19\" target=\"_blank\" rel=\"noreferrer noopener\">Science<\/a> magazine.\u00a0<\/p>\n\n\n\n<p class=\"wp-block-verse\" style=\"font-size: 18px; text-align: justify;\">Arcturus Therapeutics Holdings, located in San Diego, California, developed the vaccine ARCT-154. The trials are now underway in Vietnam with 17,000 participants. According to a press statement from <a href=\"https:\/\/ir.arcturusrx.com\/news-releases\/news-release-details\/arcturus-announces-self-amplifying-covid-19-mrna-vaccine\" target=\"_blank\" rel=\"noreferrer noopener\">Arcturus<\/a>, it provided <strong>95% protection against severe Covid-19 and death and 55% against Covid infection<\/strong>. It&#8217;s the first time to show a self-amplifying RNA vaccine as safe and effective.\u00a0<\/p>\n\n\n\n<p class=\"wp-block-verse\" style=\"font-size: 18px; text-align: justify;\">The effectiveness rate of 55% is lower than the 90-95% recorded in studies of the first two Pfizer-BioNTech and Moderna vaccines. According to Science magazine, those vaccines were tested when the original SARS-CoV-2 virus was circulating. The Arcturus vaccine, which was based on a similar strain, had to protect against the Delta and Omicron variants circulating in Vietnam during the trial, which had mutated significantly from the original strain, reducing the potency of vaccine-triggered antibodies.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>How is this vaccine different from previous mRNA vaccines?<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-verse\" style=\"font-size: 18px; text-align: justify;\">The Pfizer-BioNTech and Moderna vaccines use messenger RNA (mRNA), which encodes the SARS-CoV-2 spike protein. The vaccines transfer the mRNA to cells, instructing them to create<strong> copies of the spike protein<\/strong>, and the foreign genetic material is then cleared out within a few days.<\/p>\n\n\n\n<p class=\"wp-block-verse\" style=\"font-size: 18px; text-align: justify;\">The self-amplifying COVID-19 mRNA vaccine developed by Arcturus and others under development is an improvement on the standard mRNA platform. They include enzymes that produce several <strong>copies of the original mRNA<\/strong> inside a cell, allowing it to<strong> last more than twice as long <\/strong>in the body. The primary advantage is that it requires a <strong>lower dosage<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-verse\" style=\"font-size: 18px; text-align: justify;\">The research, which began in August 2021, provided participants with two doses of the self-amplifying mRNA, each containing 5 micrograms, spaced 28 days apart. The Pfizer-BioNTech and Moderna vaccines employ 30-microgram and 100-microgram dosages for the first two shots, respectively.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Implications<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-verse\" style=\"font-size: 18px; text-align: justify;\">Moderna and Pfizer-BioNTech vaccines are now considered gold standards. Arcturus vaccine may be new and late to the market. Still, it might have substantial benefits, including <strong>simpler storage and reduced costs <\/strong>due to its &#8220;self-amplifying&#8221; design, which allows for <strong>smaller dosages<\/strong>.<\/p>\n\n\n\n<\/details>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center\">Source: <a href=\"https:\/\/www.science.org\/content\/article\/mrna-vaccine-twist-it-copies-itself-protects-against-covid-19\" target=\"_blank\" rel=\"noreferrer noopener\">Science<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Data so far promises a new, lower-dose vaccine that is easier to distribute and cheaper&hellip;<\/p>\n","protected":false},"author":1,"featured_media":9155,"comment_status":"closed","ping_status":"closed","template":"","portfolio-category":[428,438,426],"class_list":["post-9151","portfolio","type-portfolio","status-publish","has-post-thumbnail","hentry","portfolio-category-428","portfolio-category-april-2022","portfolio-category-newsfeed"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New self-amplifying COVID-19 mRNA vaccine shows promising results<\/title>\n<meta name=\"description\" content=\"Self-amplifying COVID-19 mRNA vaccine produce several copies of the original mRNA inside a cell, allowing it to last more than twice as long\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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